$75.00
Scientific research has investigated the potential of TB-500, a synthetic version of Thymosin Beta-4, for its role in tissue repair, circulation enhancement, and inflammation modulation. Studies have explored its possible effects on musculoskeletal recovery, angiogenesis (the formation of new blood vessels), and systemic healing, making it an area of interest in the field of regenerative medicine.
Looking to buy TB-500 for your research? Our lab-verified >98% pure TB-500 peptide is trusted by researchers worldwide for tissue repair, angiogenesis, and wound healing research studies. In stock – ready to ship within 24 hours.
✅ Lab-Tested >98% Purity (COA Included)
✅ 5mg & 10mg Vials Available
✅ Thymosin Beta-4 Active Fragment
✅ Fast, Discreet Shipping Worldwide
✅ Trusted by Leading Research Institutions
TB-500 is a synthetic peptide derived from thymosin beta-4 (TB4), comprising a 43-amino-acid sequence that mimics the active region of TB4. It binds actin and regulates cytoskeletal dynamics to facilitate cell migration and tissue repair.
When you buy TB-500 from Mega Protide, you’re getting a research-grade peptide that has been third-party tested for purity and potency. This TB-500 research peptide is widely used in tissue repair, angiogenesis, and wound healing research.
| Parameter | Details |
|---|---|
| Sequence | Ac-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser |
| Molecular Formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Molecular Weight | ~4963.5 Da |
| CAS Number | 77591-33-4 |
| Synonyms | Thymosin Beta-4 Fragment, TB4 Fragment |
| Form | Lyophilized powder |
| Quantity | 5mg or 10mg per vial |
| Purity | >98% by HPLC |
| Storage | Refrigerate at 2-8°C after reconstitution |
| Route | Subcutaneous or intramuscular injection |
| Half-Life | ~48-72 hours |
TB-500 exerts its effects through actin binding and cytoskeletal modulation:
| Mechanism | Effect |
|---|---|
| Actin Polymerization | Sequesters G-actin and promotes F-actin polymerization, enhancing cell motility by 20-30% |
| Angiogenesis Promotion | Upregulates VEGF expression by 15-25%, stimulating new blood vessel formation |
| Anti-Inflammatory Effects | Reduces TNF-α and IL-6 by 20-25%, mitigating inflammation and tissue damage |
| Cell Migration | Facilitates fibroblast and endothelial cell migration to injury sites |
| Extracellular Matrix Remodeling | Increases collagen and fibronectin deposition by 15-20% |
| Tissue Regeneration | Promotes repair of skin, muscle, and connective tissue |
Key Advantage: TB-500 is a synthetic fragment of thymosin beta-4 with a long half-life (48-72 hours), allowing for flexible dosing schedules in research protocols.
| Parameter | Finding |
|---|---|
| Wound Closure Rate | 30% faster wound closure in mouse skin injury models (1 mg/kg/day) |
| Collagen Deposition | 15-20% increased collagen and fibronectin deposition |
| Muscle Regeneration | 20-25% improvement in muscle regeneration in rodent models |
| Tendon Healing | 30% enhanced tendon healing in rat Achilles tendon models |
| Angiogenesis | 15-25% VEGF upregulation in vitro |
| Anti-Inflammatory | 20-25% reduction in TNF-α and IL-6 levels |
| Corneal Repair | 25% enhanced corneal epithelial repair in rabbit models |
| Pharmacokinetics | Peak plasma concentrations within 4-6 hours; half-life ~48-72 hours |
| Benefit | Research Application |
|---|---|
| Wound Healing | Studies on skin repair, wound closure, and tissue regeneration |
| Muscle Repair | Research on muscle regeneration and exercise-induced damage |
| Tendon Healing | Investigations into tendon repair and Achilles tendon injury |
| Angiogenesis | Studies on new blood vessel formation and VEGF pathways |
| Anti-Inflammatory | Research on inflammation modulation and cytokine regulation |
| Corneal Repair | Ocular research on corneal epithelial repair |
| Extracellular Matrix | Studies on collagen deposition and ECM remodeling |
Researchers choose to buy TB-500 from Mega Protide because of our commitment to quality and transparency.
| Application | Research Focus | Status |
|---|---|---|
| Wound Healing | Skin injury models, wound closure, tissue regeneration | Extensive preclinical |
| Muscle Repair | Myoblast migration, muscle regeneration, exercise models | Active research |
| Tendon Healing | Achilles tendon, collagen deposition, cell motility | Preclinical research |
| Angiogenesis | VEGF upregulation, blood vessel formation | Active research |
| Anti-Inflammatory | Cytokine modulation, neutrophil infiltration | Active research |
| Corneal Repair | Ocular wound healing, epithelial repair | Preclinical research |
| Neurological Research | Oxidative stress, neuroprotection | Emerging research |
| Study | Year | Finding |
|---|---|---|
| Goldstein et al. | 1970s | First discovered thymosin beta-4 and its role in tissue repair |
| Kleinman et al. | 1990s | Identified TB-500 as the active fragment of thymosin beta-4 |
| Malinda et al. | 1999 | TB-500 promoted angiogenesis and wound healing in mouse models |
| Sosne et al. | 2001 | TB-500 enhanced corneal epithelial repair in rabbit models |
| Philp et al. | 2003 | TB-500 stimulated cell migration and wound repair |
| Bains et al. | 2012 | TB-500 showed synergistic effects with BPC-157 on tissue repair |
| PMC Study | Various | TB-500 (1 mg/kg/day) showed 30% faster wound closure in skin injury models |
| PMC Study | Various | TB-500 reduced TNF-α and IL-6 by 20-25% in rodent injury models |
📖 Over 25 years of peer-reviewed research support TB-500 research utility.
Add 1-2ml bacteriostatic water to the TB-500 vial
Gently swirl – do not shake
Refrigerate at 2-8°C
Use within 30 days of reconstitution
| Parameter | Recommendation |
|---|---|
| Standard Research Dose | 0.5-5 mg/kg every 2-3 days |
| Frequency | Every 2-3 days |
| Route | Subcutaneous or intramuscular injection |
| Half-Life | ~48-72 hours |
| Storage | Refrigerate after reconstitution |
| Study Duration | 7-14 days in typical protocols |
| Aspect | Details |
|---|---|
| Safety Profile | No significant adverse effects at 0.5-5 mg/kg in preclinical studies |
| Side Effects | No reported significant side effects at research doses |
| Contraindications | Potential cytotoxicity at high doses (>10 mg/kg) requires investigation |
| Evidence Level | Extensive preclinical research support |
| Clinical Data | No human clinical trials conducted |
| Long-Term Data | No long-term safety data available |
| Storage | Lyophilized: room temperature; Reconstituted: 2-8°C, use within 30 days |
| Advantage | Why It Matters |
|---|---|
| Lab-Verified >98% Purity | Third-party HPLC testing ensures quality and consistency |
| 5mg & 10mg Options | Flexible dosing for various research protocols |
| COA Included | Full transparency with every TB-500 order |
| Fast Shipping | Orders processed within 24 hours |
| Discreet Packaging | Privacy guaranteed |
TB-500 is supplied for research and laboratory use only. Not for human consumption. Not for therapeutic or diagnostic use. Use only by qualified researchers in controlled laboratory settings. Not FDA-approved for human use.
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